Neurostimulation (TMS & tDCS)

Transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are non-invasive methods that modulate neuronal excitability in both directions in subcortical and cortical networks.

tDCS uses a weak constant current to influence membrane polarisation and the probability of spontaneous firing, producing plastic changes similar to long-term potentiation (LTP) or depression (LTD). TMS triggers action potentials with brief, intense magnetic pulses, which makes it a powerful tool for studying cortical circuits and motor excitability.

• tDCS / tACS
• TMS / rTMS
• Theta burst stimulation
• Neuroplasticity
• Cortical mapping
• Neurorehabilitation
• ECS mapping

Unicorn tDCS Core-2 is a fully portable, smartphone-controlled 2-channel tDCS system designed for research on subcortical and cortical plasticity. It attaches magnetically to the cap with Snap-In technology, and the researcher chooses the cathode and anode positions freely. Anodal stimulation raises cortical excitability in the target region (LTP-like); cathodal stimulation depresses it (LTD-like).

In the Android app you set the stimulation current (0–2 mA), ramp time and session length; sham (placebo) conditions support double-blind designs. Soft g.SAHARA electrodes can target frontal (DLPFC, OFC), motor (M1), parietal and occipital regions and are compatible with simultaneous EEG recording protocols. The device is CE-marked and RoHS compliant.

• 0–2 mA
• 1 cathode + 1 anode
• 3 h 30 min active battery
• Bluetooth 5
• 45 g
• CE, EMC, RoHS
• Sham protocol

g.ESTIM PRO is a constant-current biphasic electrical stimulator used for functional brain mapping (ECS) before cortical resections. It is designed to IEC 60601-1, IEC 60601-2-40 and ISO 14971, and is a CE-marked, FDA-cleared medical device.

With an 80 V compliance voltage it delivers the required current into high-impedance ECoG and cortical electrodes. Used with g.USBamp or g.HIamp, it lets you design closed-loop stimulation experiments with real-time EEG/ECoG recording in g.HIsys.

• ± 0.2–15 mA
• Biphasic rectangular
• 0.1–1.0 ms phase duration
• 2–100 pulses/s
• 80 V
• CE + FDA

Developing TMS technology since 1992, MagVenture offers comprehensive systems, with the MagPro series of stimulators and a wide range of coils, that support rTMS, theta burst stimulation (TBS), paired-pulse and cortical mapping protocols. All products are made in Denmark.

MagVenture's distributor in Türkiye is Vascomed; as Vascomed's partner, Nevosa offers access to these products and consulting support.

MagPro R30 is a high-performance TMS stimulator supporting a wide range of clinical protocols, above all for major depressive disorder, OCD and chronic pain. It runs continuously for up to 20,000 pulses in a single session, and automatic protocol sequencing handles complex multi-protocol sessions.

It supports repetition rates of 30, 60 and 80 pps; with the optional theta burst (TBS) module, intermittent and continuous TBS protocols can be applied. EMG and EEG trigger I/O allows synchronisation with other recording systems. It is FDA cleared.

• rTMS
• Theta burst (TBS)
• 30 / 60 / 80 pps
• FDA
• EMG / EEG trigger

MagPro X100 is a magnetic stimulator with high repetition capacity, optimised for basic and translational neuroscience research. It supports biphasic and monophasic pulse shapes, and electronic current-direction reversal allows stimulation in both directions through the same coil.

The MagOption add-on adds twin-coil paired-pulse, power mode and half-sine waveforms. With repetition rates up to 100 Hz, cortical excitability (MEP), cortical silent period (CSP), short-interval cortical inhibition (SICI) and other paired-pulse protocols can be run.

• 100 Hz
• Biphasic / monophasic
• Paired-pulse
• MEP / CSP / SICI
• MagOption